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Eligibility
INCLUSION CRITERIA
You must meet all of the following...
  • Female
  • Aged 18-75 years
  • Resident in greater Seattle metropolitan area (King Country), Pierce or Snohomish Counties
  • Healthy
  • Able to perform all study requirements, including attendance at clinic visits and capable of responding to questionnaires and clinic and exercise facility instructions in English
  • Willing to be assigned by chance by a computer program to either the exercise or control group
  • Capable of providing informed consent
EXCLUSION CRITERIA
You cannot participate if any of the following are true...
  • Pregnant in past 3 months
  • Currently breast feeding
  • Current use of any tobacco products including smoking, vaping, chew, nicotine patches
  • History of diabetes mellitus or high blood sugar that could indicate diabetes
  • Taking any medications to treat high blood sugar such as metformin
  • History of any cancer (other than non-melanoma skin cancer)
  • Drinking more than 2 alcoholic drinks/day
  • Ever told by a doctor that you should NOT exercise
  • Findings on the physical exam that could make exercise unsafe
  • History of heart attack, stroke, heart failure, heart valve disease, heart rhythm problems, serious lung disease, blood clot in the lungs, uncontrolled high blood pressure
  • Frequent marijuana use (more than once per month)
  • Alcohol or drug dependence or abuse, or uncontrolled mental illness
  • In Premenopausal women:
    • irregular periods for the past 6 months
    • use of oral contraceptives for the previous 3 months
    • use of hormone implants or IUD with hormones (e.g. Mirena) in the previous year
    • use of estrogens, progesterone, testosterone or other androgens for the previous 3 months
  • In Postmenopausal women:
    • use of estrogen, progesterone, testosterone, or other androgens in the previous 3 months, of any type including oral, creams, vaginal creams or inserts, patches, or implants
EXCLUSIONS FOR THE MUSCLE-BIOPSY SUB-STUDY
You cannot participate in the sub-study if any of the following are true...