Acute Effects of Exercise on Breast Cancer Biomarkers (ACE) Study
INCLUSION CRITERIA
Female with a history of Stage 0-3 breast cancer diagnosed within the past 5 years
Aged 36–75 years
Completed treatment at least 6 months ago (if you are taking long-term hormone treatment you may still be eligible)
Resident in Washington State, and willing to come to the Fred Hutch Campus in South Lake Union, Seattle for 2 clinic visits
Able to perform all study requirements, capable of responding to questionnaires and clinic and exercise facility instructions in English
Willing to be assigned by chance by a computer program to either the exercise or control group
Capable of providing informed consent
Consent to release medical records to verify cancer diagnosis and to review health information
No menstrual period for the past 12 months (due to either menopause, surgery or a side-effect of treatment)
EXCLUSION CRITERIA
Pregnant or currently breast feeding
Premenopausal women
Use of estrogens, progesterone, testosterone, or other androgens for the previous 3 months
Postmenopausal women
Use of estrogen, progesterone, testosterone, or other androgens in the previous 3 months of any type including oral, creams, vaginal creams or inserts, patches, or implants
Current use of any tobacco products including smoking, vaping, chew, nicotine patches
Other cancers apart from non-melanoma skin cancer and cervical neoplasia (CIN)
History of diabetes mellitus or high blood sugar that could indicate diabetes
Taking any medications to treat high blood sugar such as metformin
History of cancer other than breast (other than non-melanoma skin cancer)
Drinking more than 2 alcoholic drinks/day
Ever told by a doctor that you should NOT exercise
Findings on the physical exam that could make exercise unsafe
History of heart attack, stroke, heart failure, heart valve disease, heart rhythm problems, serious lung disease, blood clot in the lungs, uncontrolled high blood pressure
Frequent marijuana use (more than once per month)
History of clotting disorders
Unable or unwilling to stop aspirin, ibuprofen, naproxen, or similar drugs for 48 hours before and after the procedure
Allergy to anesthetics including local anesthetics
