ACE Logo

Acute Effects of Exercise
on Breast Cancer Biomarkers (ACE) Study

  • Female with a history of Stage 0-3 breast cancer diagnosed within the past 5 years
  • Aged 36–75 years
  • Completed treatment at least 6 months ago (if you are taking long-term hormone treatment you may still be eligible)
  • Resident in Washington State, and willing to come to the Fred Hutch Campus in South Lake Union, Seattle for 2 clinic visits
  • Able to perform all study requirements, capable of responding to questionnaires and clinic and exercise facility instructions in English
  • Willing to be assigned by chance by a computer program to either the exercise or control group
  • Capable of providing informed consent
  • Consent to release medical records to verify cancer diagnosis and to review health information
  • No menstrual period for the past 12 months (due to either menopause, surgery or a side-effect of treatment)
  • Pregnant or currently breast feeding
  • Premenopausal women
    • Use of estrogen, progesterone, testosterone, or other androgens for the previous 3 months
  • Postmenopausal women
    • Use of estrogen, progesterone, testosterone, or other androgens in the previous 3 months of any type including oral, creams, vaginal creams or inserts, patches, or implants
  • Current use of any tobacco products including smoking, vaping, chew, nicotine patches
  • History of diabetes mellitus or high blood sugar that could indicate diabetes
  • Taking any medications to treat high blood sugar such as metformin
  • History of cancer other than breast (other than non-melanoma skin cancer)
  • Drinking more than 2 alcoholic drinks/day
  • Ever told by a doctor that you should NOT exercise
  • Findings on the physical exam that could make exercise unsafe
  • History of heart attack, stroke, heart failure, heart valve disease, heart rhythm problems, serious lung disease, blood clot in the lungs, uncontrolled high blood pressure
  • Frequent marijuana use (more than once per month)
  • History of clotting disorders
  • Unable or unwilling to stop aspirin, ibuprofen, naproxen, or similar drugs for 48 hours before and after the procedure
  • Allergy to anesthetics including local anesthetics
  • Long term use of warfarin or similar medications